Pioneers in COVID-19 averse antibody drug development

Daily Covid-19 cases in Australia rise by 100,000 for the first time

Below is an outline of where the major drugmakers are in the development and regulatory process:

AstraZeneca, Eli Lilly, Regeneron and GlaxoSmithKline are among the greatest pharmaceutical organizations to have created COVID-19 treatments utilizing a class of drugs called monoclonal antibodies, however the spread of the exceptionally infectious Omicron variation has placed the treatments’ effectiveness into question. Lab-made monoclonal antibodies mimic natural antibodies in fighting off diseases. Not at all like vaccines they don’t depend on the body to make an immune reaction, and can consequently assist people with weak or compromised immune systems.

ASTRAZENECA

* AstraZeneca’s AZD7442 is a combination of two monoclonal antibodies given in two sequential injections and aimed at preventing and treating COVID-19.

* On Oct. 5 it requested emergency use approval (EUA) from U.S. regulators as a preventative drug.

* On Oct. 11 it said it would also submit the new treatment data to global health regulators.

* On Oct. 14, the EU drug regulator said it had started a real-time review of the therapy.

TRIALS:

* In June, the drugmaker said a late-stage trial had failed to provide evidence that the therapy could stop individuals exposed to the virus from contracting it. * In August, another trial showed the therapy reduced the risk of people developing any COVID-19 symptoms by 77%.

* On Oct. 11 data showed AZD7442 reduced the risk of severe COVID-19 or death by 50% in non-hospitalised patients who have had symptoms for seven days or less. SUPPLY DEALS:

* AstraZeneca said in March it would supply up to 500,000 more doses of the therapy to the United States, extending a prior agreement made in October for 200,000 doses. The deal is contingent on an EUA from the FDA. * The British government also has an in-principle agreement for over a million doses.

ELI LILLY & CO * U.S. pharmaceutical group’s treatment, a combination of the antibodies bamlanivimab and etesevimab, is meant for patients with mild-to-moderate COVID-19.

* In February it was granted EUA by the FDA for treatment of patients at high risk of severe illness who have not been hospitalised or require oxygen therapy. * The U.S. Department of Health and Human Services paused distribution in June after the drug failed to show effectiveness against several COVID-19 variants, but resumed it to some states at the end of August.

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