Positive Results Observed on Safety, Activation of Gamma 9 Delta 2 T Cells and Anti-tumor Immune Response

Positive Results Observed on Safety, Activation of Gamma 9 Delta 2 T Cells and Anti-tumor Immune Response

News Highlights

  • ICT01 activates γ9δ2 T cells that rapidly migrate out of the circulation and secrete IFNγ and TNFα leading to an expanded immune system activation
  • Increased densities of activated and proliferating γδ, CD3+ and CD8+ T cells were observed in tumor biopsies post ICT01 treatment

Marseille, France, April 9, 2021ImCheck Therapeutics announced today that data from its ongoing EVICTION Phase I/IIa clinical trial will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2021 in an oral presentation (CT034) by Aurélien Marabelle, MD, PhD, Lead Investigator for EVICTION, titled: “Activation of the anti-tumor immune response of γ9δ2 T cells in patients with solid or hematologic malignancies with ICT01, a first-in-class, monoclonal antibody targeting Butyrophilin 3A: The EVICTION study”, on April 11, 2021 from 4:50 – 5:00 PM US ET in the CTMS03 – Clinical Trials with Novel Immuno-oncology Strategies session.

ICT01 is a first-in-class, anti-BTN3A monoclonal antibody that activates γ9δ2 T cells, a subset of tumor infiltrating lymphocytes that have potent cytotoxic effects on solid and hematologic cancer cells and can activate other immune cells against the cancer. To the company’s knowledge, the data that will be presented is the first demonstration of an activating antibody safely and dose-dependently engaging γ9δ2 T cells that also coordinate an anti-tumor immune response from the innate and adaptive immune systems.

The ongoing EVICTION trial is evaluating ICT01 in patients with advanced, relapsed/refractory solid and hematologic cancers with no remaining standard of care. The abstract published today covers results from four cohorts of patients with solid tumors (n=20) and one cohort of patients with hematologic cancer (n=3) and demonstrated that ICT01 monotherapy, at doses from 20 µg to 20 mg, achieved safe and potent activation of the anti-tumor immune responses of γ9δ2 T cells.

Across the cohorts treated, more than 95% of γ9δ2 T cells migrated out of the circulation at all four ICT01 doses. Levels of IFNγ and TNFα increased in a generally dose-dependent manner, which correlated with baseline γ9δ2 T cell counts, and activation and migration of NK and CD8+ T cells from the circulation at doses ≥7 mg. The second ICT01 administration induced similar cell activation and trafficking. Immunhistochemical staining showed a significant increase in γδ, CD3 and CD8  T cells in several tumor biopsies post ICT01 treatment, indicating that ICT01, via tumor-infiltrating activated γ9δ2 T cells, induces a broad anti-tumor immune response within the tumor microenvironment.

“These new data from increasing doses of ICT01 indicate that ICT01 safely and dose-dependently activates γ9δ2 T cells that induce an expanded immune system activation within the blood and tumor, which supports our proposed mechanism of action,” commented Aurélien Marabelle, MD, PhD, Immuno-Oncologist at Gustave Roussy, Villejuif, France and Lead Investigator for EVICTION, who will present the data at the AACR. “We look forward to completing Part 1 and initiating Part 2 where we will test  the efficacy of ICT01 in target patient populations.”

“As a first-in-class, immune system-activating mAb, we are encouraged to see rapid and potent dose-dependent activity of ICT01 without any safety concerns in the patients treated to date. We are now more than halfway through patient recruitment for Part 1 of the trial and we remain on target to report on the topline results in 2021,” said Paul Frohna, MD, PhD, Chief Medical Officer at ImCheck Therapeutics. “We are thankful for the efforts of the EVICTION investigators and their study teams, and their patients’ willingness to participate in our trial despite the ongoing pandemic.”

Following multiple safety reviews by the independent Safety Review Committee, the EVICTION trial has continued to dose escalation in all arms of the study.

The AACR presentation slides will be available starting April 11, 2021 at 5:00 pm US Eastern Time / 23:00 CET on ImCheck’s corporate website.

***

About the EVICTION Trial

EVICTION is a first-in-human, dose escalation (Part 1) and cohort expansion (Part 2) clinical trial of ICT01 in patients with various advanced solid or hematologic cancers that have exhausted standard of care treatment options. Part 1 is a basket trial designed to characterize the preliminary safety, tolerability, and pharmacodynamic activity of ICT01 as monotherapy (Group A: solid tumors; Group B: hematologic tumors) and in combination with pembrolizumab (Group C: solid tumors). Group A includes bladder, breast, colorectal, gastric, melanoma, ovarian, prostate, and pancreatic cancer, Group B includes AML, ALL, follicular lymphoma, and diffuse large B cell lymphoma, and Group C includes bladder, HNSCC, melanoma, and NSCLC. Basket trials represent a clinical trial design that allows new drugs to be tested rapidly in a range of indications, providing initial results on multiple parameters that can contribute to an accelerated development timeline.  More information on the EVICTION trial can be found at clinicaltrials.gov (NCT04243499).

About ICT01

ICT01 is a humanized, anti-BTN3A (also known as CD277) monoclonal antibody that selectively activates γ9δ2 T cells, which are part of the innate immune system that is responsible for immunosurveillance for malignancy and infection. The 3 isoforms of BTN3A targeted by ICT01 are expressed on the surface of innate (e.g., γδ T cells and NK cells) and adaptive immune cells (T cells and B cells) and are overexpressed on a number of solid tumors (e.g., bladder, colorectal, melanoma, ovarian, pancreatic, lung) and hematologic cancers (e.g., leukemia & lymphoma). BTN3A is essential for the activation of the anti-tumor immune response of γ9δ2 T cells.

ICT01 selectively activates circulating γ9δ2 T cells that leads to migration of γ9δ2 T cells out of the circulation and into target tissue (e.g., tumors or infection site), while also activating the tumor-resident γ9δ2 T cells to directly kill malignant cells, which is accompanied by secretion of two key inflammatory cytokines, IFNg and TNFa, that expand the anti-tumor immune response. ICT01 has been shown to have anti-tumor activity against a range of cancers in in vitro and in vivo tumor models.

About IMCHECK THERAPEUTICS

ImCheck Therapeutics is designing and developing a new generation of immunotherapeutic antibodies targeting butyrophilins, a novel super-family of immunomodulators.

As demonstrated by lead clinical-stage program ICT01, which has a mechanism of action to simultaneously modulate innate and adaptive immunity, ImCheck’s “first-in-class” activating antibodies may be able to produce superior clinical results as compared to the first-generation of immune checkpoint inhibitors and, when used in combination, to overcome resistance to this group of agents. In addition, preclinical experiments with ImCheck’s antagonist antibodies have shown their potential as treatments for a wide range of autoimmune diseases.

Co-founder of the Marseille Immunopole cluster, ImCheck benefits from support from Prof. Daniel Olive (INSERM, CNRS, Institut Paoli Calmettes, Aix-Marseille Université), a worldwide leader in γδ T cells and butyrophilins research; from the experience of an expert management team; and from the commitment of leading US and European investors. 

For further information on ImCheck: http://www.imchecktherapeutics.com and @ImCheckThx

Press contacts

US and EU Trophic CommunicationsGretchen Schweitzer +49 (0) 172 861 8540 imcheck@trophic.eu

FranceATCG-PARTNERSCéline Voisin+33 (0)9 81 87 46 72 / +33 (0)6 62 12 53 39imcheck@atcg-partners.com

 

  • Check the latest Health news updates and information.
  • Please share this news Positive Results Observed on Safety, Activation of Gamma 9 Delta 2 T Cells and Anti-tumor Immune Response with your friends and family to support us your one share helps us a lot.
Disclaimer: If you need to edit or update this news from compsmag then kindly contact us Learn more

For Latest News Follow us on Google News


Trending Lists

Best SD Card Reader
Best SD Card Reader of 2021
Are you looking for the Best SD Card Reader of 2021? If you are a professional photographer who often uses various memory cards or if you need a…read more ❯
best photo printers
Best Photo Printers
When it comes to making high-quality photo prints at home, the inkjet market has narrowed to a two-person race. HP and Lexmark have become more…read more ❯
Best Headphones Under $50
Best Headphones Under $50
Do you have a small budget to work, and do you need good quality headphones that you can count on? In this guide, you will find the Best Headphones…read more ❯
Best Gaming Mouse Under $80
Best Gaming Mouse Under $80
Are you looking for the Best Gaming Mouse Under $80? Gaming mice improve your performance. One can not deny it. Far from their rollerball ancestors,…read more ❯
Best Bluetooth Speakers Under $50
Best Bluetooth Speakers Under $50
Do you have a small budget and do you need high-quality and Best Bluetooth Speakers $50? In this guide, you will find some for the Best options…read more ❯
Best Car Phone Mount Under $50
Best Car Phone Mount Under $50
Are you looking for the Best Car Phone Mount Under $50? Driving with your phone in your hands and using your GPS can often be a great danger. You…read more ❯
Best Protein Powders For Women In India
Best Protein Powders For Women In India
Are you looking for the Best Protein Powders For Women In India? It’s time to change the conversation about fitness. We must stop worrying about…read more ❯
Best Green Screen Backgrounds
Best Green Screen Backgrounds of 2021
Are you looking for the Best Green Screen Backgrounds of 2021? If you are a photographer or videographer, you need The Best green screen kit and any…read more ❯

Tutorials & Guides

How to Repair OnePlus 5 IMEI Number Program
Hello guys in this guide, I am gonna tell you about How to Repair OnePlus 5 IMEI Number Program. So read this article, step by step so you may…read more ❯
How to Blur Images using Paint.NET
Hello guys in this guide, I am gonna tell you about How to Blur Images using Paint.NET. So read this article, step by step so you may understand it…read more ❯
How To Fix Samsung Galaxy S9 Plus GPS Not Accurate Problem
Hello guys in this guide, I am gonna tell you about How To Fix Samsung Galaxy S9 Plus GPS Not Accurate Problem. So read this article, step by step so…read more ❯
Making a Cov­er Page in Google Docs: Guide
This article is about Making a Cov­er Page in Google Docs: Guide. So read this free guide, Making a Cov­er Page in Google Docs: Guide step by…read more ❯
Google Keep vs Wun­derlist: Comparison and Review
This article is about Google Keep vs Wun­derlist: Comparison and Review. So read this free guide, Google Keep vs Wun­derlist: Comparison and Review…read more ❯
How to Set Mas­ter Pass­word For Your Login Details in Firefox Browser
This article is about How to Set Mas­ter Pass­word For Your Login Details in Firefox Browser. So read this free guide, How to Set Mas­ter…read more ❯
How to Syn­c Win­dows 10 Time With Microsoft Server
This article is about How to Syn­c Win­dows 10 Time With Microsoft Server. So read this free guide, How to Syn­c Win­dows 10 Time With Microsoft…read more ❯

This Easy iPhone Trick Will Save You Tons of Photo Space
How to use the icloud to free up more space We’ve all been the re: Working low on iPhone space for storing, scrambling to delete photographs we…read more ❯
8 Greatest Apps to Maximize Android perfomance
Android is not as controlled and regulated as its iOS competitor. It doesn’t matter what version of the mobile OS you are running, but with android…read more ❯
Google Play store Error 498 5 easy Methods to fix it
Just lately Whereas Downloading Asphalt game on my Smartphone I received an Error 498 in Google Play Store. To be Actual, the Error Reads “Error…read more ❯
How to Enable Copy paste in CMD – Windows
By Default Windows don’t permit users to Copy text and Paste it in Command prompt Or Copy textual content from Command prompt(cmd) and paste it…read more ❯
How to Speed Up Chrome Browser Easily
As we all know that chrome is very fast browser amongst all browser compare to firefox , internet exporer and safari and so on. However sometimes its…read more ❯
How to stop Facebook account from being hacked
There are lots of methods to lose control of your Facebook account. It’s possible you’ll get hacked and ultimately loose Control over your facebook…read more ❯
Method to watch youtube videos in vlc media player
VLC Media Player Have the Functionality to Play Movies with all most all Video Codecs , Most likely that is the One cause Why VLC media player is…read more ❯
top 4 Linux screenwriting software program
Want to put in writing the next top blockbuster, indie film or hit sitcom? We take a look at out the very best linux screenwriting software  for…read more ❯
Download YouTube Videos Offline mode on your phone
It takes just a few easy steps to download  video from YouTube app. Open a video, tap the download button (see screenshot), select the resolution…read more ❯
How to Look Better While Video Chatting
Video chatting is so commonplace nowadays that even dogs know how to do it. However, with the rise of live conferencing and Skype interviews, the…read more ❯

Latest Headlines
  • Show all
  • Trending News
  • Popular By week
Zions Bancorporation, National Association reports financial results for the first quarter of 2021

Zions Bancorporation, National Association reports financial results for the first quarter of 2021

About Zions Bancorporation, N.A. Story continues Zions Bancorporation, N.A. is one of the nation’s premier financial services companies with annual net ...
Taking control of your Ubuntu desktop

Taking control of your Ubuntu desktop

Most Linux desktops start out charmingly uncluttered. They display a handful of icons on an attractive background. These include shortcuts for launching ...
Time, TV, and more details for the Detroit Tigers vs. Oakland Athletics game

Time, TV, and more details for the Detroit Tigers vs. Oakland Athletics game

Where: Oakland Coliseum in Oakland, Calif. When: 4:07 p.m. Saturday. TV: Bally Sports Detroit. Radio: 97.1 FM in Detroit (Tigers radio affiliates). ...
Trail camera footage of barred owl a real hoot for videographer

Trail camera footage of barred owl a real hoot for videographer

There are others when something really unusual pops into the frame, and when that happens, it’s like Christmas morning for Naser. There are days when Sally ...
Inkjet Printers Market (COVID-19 Impact Analysis) 2021 to See Major Growth in Revenue

Inkjet Printers Market (COVID-19 Impact Analysis) 2021 to See Major Growth in Revenue

Few of the leading organizations’ names are listed here- Videojet Technologies, Inc., Pannier Corporation., Canon Singapore Pte. Ltd., HP Development ...
What advertisers entering the game arena should know

What advertisers entering the game arena should know

Using brand lift studies and social listening to measure value We also see that different game genres have drastically different player demographics. For ...
Dell XPS 13 OLED Touchscreen Laptop Release

Dell XPS 13 OLED Touchscreen Laptop Release

Aside from giving users an extra option in screen choices, the new XPS 13 model retains all of its previous high-performance specs. At its top configuration, ...
App store infected with the malware -Security firm- Beware of third Party App!

App store infected with the malware -Security firm- Beware of third Party App!

According to a report by Slashgear, popular third-party Android store APKPure’s official Android client was found to contain malicious code, by security firm ...
Show next
Compsmag - Latest News from tech, business and health
Logo