SNBNCBS develops nanomedicine to alter oxidative stress in body

SNBNCBS develops nanomedicine to alter oxidative stress in body

Scientists at the S.N.Bose National Center for Basic Sciences, Kolkata (SNBNCBS) have developed a safe and cost-effective nanomedicine that promises to treat a number of diseases by altering oxidative stress in the body. The research could give a glimmer of hope in India’s fight against COVID-19, as nanomedicine can reduce or increase reactive oxygen species (ROS) in our body depending on the situation and cure the disease.

The potential of this study for controlled improvement of mammalian ROS raises hopes for a new potential application of nanomedicine in the management of viral infections, including COVID-19. Animal experiments Reduction and oxidation (Redox) healing of various diseases has been completed, and now the institute is looking for sponsors to start clinical trials on humans.

The drug combines nanoparticles extracted from manganese salt with citrus extracts, such as from lemon. A critical combination of manganese and citrate using nanotechnology tricks produces nanomedicine. Artificially made nanomedicine proved important to maintain a balance between reduction and oxidation (Redox) processes in the tissues of our body. Redox reactions in cells add or remove oxygen and are essential for many processes such as generating energy in cells. The redox reactions can also make products that are harmful to cells called reactive oxygen species (ROS) and that can immediately oxidize lipids (fat), proteins and nucleic acids, accelerating the aging process. However, it should be noted that our immune cells naturally produce ROS or generate oxidative stress to kill viruses or bacteria and infected cells in our body. Controlled increases in ROS or oxidative stress thus help our immune cells perform their natural functions more efficiently.

Enhancement of oxidative stress by nanomedicine in animal tissue is also commendable and useful in curative diseases, including neonatal jaundice. Recently, the Institute has shown that the added oxidative stress after nanomedicine administration can break down bilirubin (the toxic molecule that causes jaundice), which is a cure for hyperbilirubinemia (jaundice). In a mouse trial, nanomedicine was found to be safe and rapid, reducing bilirubin levels precisely within two and a half hours. This ability of controlled enhancement of mammalian oxidative stress (ROS) allows for new potential applications of nanomedicine in managing viral infection, including COVID-19. Recently, topical administration of hydrogen peroxide, which belongs to a class of ROS, has been recommended as a way to survive COVID-19. The excess ROS was achieved by applying the chemical hydrogen peroxide into the respiratory tract through a nebulizer that is advised to inactivate COVID-19 by breaking down the viral structure. Since direct administration of hydrogen peroxide causes various complications, including direct oxidation of normal body cells, replacement of the chemical with nanomedicine would be helpful.

These findings have been published in international magazines. In October last year, an extensive review was published in the journal Bimolecular Concepts entitled “Role of Nanomedicine in Redox-mediated Molecular Healing” of all developments. The concept immediately caught the attention of international experts in the field and was recently cited as “a new front in redox medicine, the emerging field of ROS-based nanomedicine, involving nanomaterials with ROS regulatory properties, promises optimized therapeutic efficacy “. Nature magazine in March this year. The effectiveness of developed nanomedicine in balancing oxidative stress (ROS) in mice was recently tested by injecting lead (Pb) ions to cause higher oxidative stress (ROS) and liver damage. It was found that nanomedicine reduces the oxidative stress of the mammal due to exposure to lead and also helps to remove the toxic ions from the liver (popularly known as chelation therapy in medicine) and reverse the damage of the organ. ChemMedChem recently highlighted this work on the front page.

(With inputs from PIB)

Disclaimer: If you need to edit or update this news from compsmag then kindly contact us Learn more

For Latest News Follow us on Google News


Latest Headlines
  • Show all
  • Trending News
  • Popular By week
China's rate drop helps emerging market equities, but currencies rally as the dollar weakens
China’s rate drop helps emerging market equities, but currencies rally as the dollar weakens
China’s main stock indexes rose 1.6 percent and 2% after Beijing cut the five-year loan prime rate by 15 basis points (bps) to 4.45 percent to help the ...
According to FDA, Abbott baby formula manufacturing will reopen in 1-2 weeks
According to FDA, Abbott baby formula manufacturing will reopen in 1-2 weeks
“I’m pleased to say today we’ve already made significant progress and I think we are on track to get it open within the next week to two weeks, most likely ...
Exclusive Super Follows spaces are now accessible in Twitter for Android, iOS and web users
Exclusive Super Follows spaces are now accessible in Twitter for Android, iOS and web users
The company has announced that it is now rolling out Super Follows-exclusive Spaces. As the name suggests, these spaces would be exclusive for Super Follows ...
As Tether, Luna and Terra crumble, the crypto system faces regulation
As Tether, Luna and Terra crumble, the crypto system faces regulation
In simple terms, TerraUSD’s one-to-one peg with the US dollar was maintained by an arbitrage with its sister coin, Luna. The coins are interchangeable, with ...
Microsoft Bing is strongly encouraged by the recent Windows 11 upgrade
Microsoft Bing is strongly encouraged by the recent Windows 11 upgrade
In a blog post, Microsoft says it’s looking into “lightweight interactive content” for its operating system, with the first Windows 11 update bringing about ...
The first game with Intel Arc A730M technology Laptop arrived in stores
The first game with Intel Arc A730M technology Laptop arrived in stores
Well here’s an Intel Arc status update: little Alchemist is available, big Alchemist still isn’t. Unless you live in China, anyway, where online marketplace ...
'Retail Apocalypse': Inflation-driven profit cuts rock Wall Street
‘Retail Apocalypse’: Inflation-driven profit cuts rock Wall Street
Retail profits were hit by higher staffing expenses, bloated inventories, and more expensive fuel, leading to a market collapse that saw Wall Street post its ...
On June 28th, Escape Academy will bring the escape room experience to PS5 and PS4
On June 28th, Escape Academy will bring the escape room experience to PS5 and PS4
The game was announced a couple of months ago with a loose release window of June this year. Now, the studio has confirmed Escape Academy will launch on 28th ...
After all, PS1 games on PS Plus Premium may have trophies
After all, PS1 games on PS Plus Premium may have trophies
Agency intel reports that Syphon Filter will include Trophies when it arrives on the all-new PlayStation Plus. pic.twitter.com/YVdMixZxBR— Bend Studio is ...
Sebi introduces a new security cover certificate format and updates the term
Sebi introduces a new security cover certificate format and updates the term
It has specified the manner of preparation of security cover certificate by listed entity and DT. In addition, Sebi has revised timelines of submission of ...
Show next
We will be happy to hear your thoughts

Leave a reply

Compsmag - Latest News In Tech and Business
Logo