The UK had about 100 million doses on order, after it increased its request by 40 million in February.
French vaccine maker Valneva says the UK government has scrapped a deal for its Covid-19 vaccine.
The company said in a statement that the UK government served notice over allegations of a breach of the agreement, which it “strenuously denies”.
Valneva’s jab is still being tested in trials.
Valneva’s stock had almost quadrupled in the past year on optimism its shot would complement existing vaccines with a different approach. The product, which is up against AstraZeneca Plc’s in clinical tests, is an inactivated vaccine — an old-school method also used for polio and hepatitis inoculations. Because it targets the whole virus rather than just the spike protein, some scientists expect it could potentially stand up better to variants. “We continue to see significant value in Valneva’s Covid-19 vaccine, but its route to market is now far less clear,” said Max Herrmann, an analyst at Stifel.
Valneva’s shot is on track for initial approval later this year. Besides the vaccine order, the U.K. government has invested in a manufacturing site in Scotland. “The news comes as a real surprise since the U.K. helped Valneva to fund development of the vaccine candidate as well as the manufacturing site extension,” Jean-Jacques Le Fur, an analyst at Bryan Garnier, wrote in a note.
Valneva didn’t answer a call and didn’t immediately respond to an email seeking comment. In the statement, the company said it had “worked tirelessly, and to its best efforts” to meet the agreement and that it will increase its efforts to find other potential customers. The inactivated vaccine works by taking a sample of the disease that has been killed and using it to stimulate an immune response without creating infection. The Valneva shot could protect against variants that might compromise vaccines focused on the virus’s spike protein, making it the perfect booster.
The discord also affects Dynavax Technologies Corp., a U.S. firm that supplies Valneva with a vaccine adjuvant. Dynavax shares slumped before U.S. exchanges opened as the company said Valneva doesn’t have an obligation to pay the final portion of an outstanding purchase order if the U.K. government reduces or terminates its contract with the drugmaker. For now, the order hasn’t been canceled.
“Innovation means taking risks,” Olivier Nataf, the head of AstraZeneca in France, said on BFM radio. “This is clearly a blow. It’s important to have a new vaccine, a new technology that would complement the others.” Astra, based in Cambridge, England, has also experienced difficult interactions with governments in France and other European Union countries, where its vaccine has taken a backseat to messenger RNA rivals despite evidence that side effects are rare and that it protects effectively against Covid.
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